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What they found: Preventive administration: 70 to 85 % reduction in ulcer area Therapeutic administration: 60 to 75 % reduction And now the most interesting part: 10 ng/kg worked just as well as 10 g/kg Why it matters: If the molecule worked in a stoichiometric way (= simply blocking something piece by piece), a higher dose would necessarily produce a larger effect

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Enzyme-linked immunosorbent assay (ELISA) For the ligandreceptor affinity ELISA, the human FBXO22 protein served as an antigen to coat the 96-well plate at 4 C for 24 h