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You are doing everything you were told to do, and the medication that was supposed to solve the problem seems to be making it worse
Reported pathways include TGF- signaling, antioxidant defense (superoxide dismutase, glutathione peroxidase), extracellular-matrix gene expression (collagen types I and III, decorin, perlecan), and inflammatory cytokine modulation
The triple mechanism hits weight loss from more angles simultaneously
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The first-line treatment with vildagliptin/pioglitazone (both high- and low-dose regimens) provided better glycemic control than each component monotherapy with minimal hypoglycemia
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