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1a) and plasma alanine aminotransferase (ALT) levels (Fig

PRPP synthetase is the enzyme responsible for the synthesis of the activated ribose (5-phosphoribosyl-1-pyrophosphate, PRPP) necessary for the de novo synthesis of purine and pyrimidine nucleotides

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Additionally, various lysine-based peptidomimetics enhance the activity of rifampicin, clarithromycin, and azithromycin against different bacteria by disrupting membrane permeability 17

Several tissue engineering approaches, such as cell sheets, scaffolds, hydrogels, microspheres, 3D bioprinting, microfluidic systems, and liver organoids, have been used to mimic the hepatic environment