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Without intrinsic factors, the body cannot absorb B12 appropriately from food
This form may still offer benefits, but efficacy can vary
In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]
This is why injections are a standard medical treatment for conditions like pernicious anemia, malabsorption syndromes, and deficiencies related to gastrointestinal disease or surgery
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