Similarly, differentiation of human iPSC-derived NSCs into neurons and glia has been shown to correlate with increased NRF2 signaling, presumably to compensate for the shift to a more oxidative metabolism, as mentioned above
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The PPP in erythrocytes is the only pathway for these cells to produce NADPH, therefore, any defect in the production of NADPH, such as due to deficiencies in glucose-6-phosphate dehydrogenase, will have profound effects on erythrocyte survival
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