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However, because the CVOTs were conducted on a background of standard of care [2,3,4,5,6,7], the majority of trial participants were receiving concomitant metformin

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No events of severe hypoglycaemia requiring hospitalization were observed (Table 4)

Although we cannot rule out that the increased production of ROS in 3D culture conditions may not be observed under hypoxia, it should be noted that hypoxia itself induces ROS production in numerous cell types, including tumor cells [39]

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors