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In the insulin regimen analysis, the proportion of patients with any on-treatment AE was somewhat higher in the patients receiving oral semaglutide added to basal-bolus insulin (8287%) than among those receiving oral semaglutide plus basal (6582%) or premixed (6980%) insulin, but no such trend was evident in the incidence of gastrointestinal or serious AEs, or in those leading to trial product discontinuation (see Table S2 in the Supplementary Information)
Autons team writes that such discrepancies may stem from differences in disease context, smaller sample sizes, limited statistical power, and variations in drug type, cohorts, and analytical methods
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Can dietary supplement ingredients mimic these effects more safely
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