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To allow broad clinical adoption, the field should establish unified data standards and a shared platform to facilitate multidisciplinary collaboration and communication [649,650,651]

In the animal kingdom, activation of the adaptive cellular mechanisms leads to interference with immune homeostasis resulting in inflammation

For instance, IL-6, a cytokine produced by various cells in the tumor microenvironment of multiple cancers, not only directly acts on tumor cells but also induces the expression of STAT3 target genes

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The initiation of BBB disruption can be direct, for example, due to an infection, or can be triggered by the activation of neuroinflammatory pathways following brain damage