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Gastrointestinal effects and referred pain: The pronounced gastrointestinal side effects of GLP-1 therapyparticularly nausea, constipation, and abdominal distensioncan occasionally manifest as referred pain to the back

A not-so-obvious but very beneficial effect of semaglutide includes its impact on the brain

Gastrointestinal issues are usually strongest in first-time users, or when people step up to a larger dosage, but they usually dissipate over time

The metabolic benefits are reported in a few days post-bariatric surgery, which suggest a weight-independent effect [70]