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When the vascular wall is stimulated by hypoxia, mechanical damage, or platelet-derived growth factor (PDGF-BB), the transcription coactivator MYOCD and the nuclear transcription factor EIkI compete for the same binding site on the serum response factor, and the contractile phenotype-responsive SRF-MYOCD complex is converted to the synthetic phenotype-responsive SRF-ELK1 complex, prompting the VSMCs to transform from a contractile phenotype to a synthetic phenotype [43, 44]
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Glutathione is not suitable for all
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"An update on lisdexamfetamine dimesylate for the treatment of attention deficit hyperactivity disorder." Expert opinion on pharmacotherapy 14.1 (2013): 137-145
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