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doi: 10.3389/fcell.2026.1898983 Received 03 June 2026 Revised 23 June 2026 Accepted 09 July 2026 Published 03 August 2026 Volume 14 - 2026 Edited by Lei Yang, University of Chinese Academy of Sciences, China Reviewed by Sajjad Hejazi, Near East University, Cyprus Amin Jalilvand, Kermanshah University of Medical Sciences, Iran Updates Copyright 2026 Wu, Zhang, Han, Ping, Xia, Ding, Yuan, Wang and Qin

By serving as an immediate treatment option that reduces addictive drive without precipitating withdrawal symptoms, GLP-1 supported initiation onto buprenorphine and naltrexone may improve success rates by making it easier for patients to reach the short-term withdrawal thresholds required to begin treatment

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Even moderate exercise such as brisk walking for 30 minutes most days can improve mental clarity, mood, and overall wellbeing