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The results indicated that pretreatment with 10 M ERK1/2 inhibitor obviously antagonized, while pretreatment with 10 M JNK inhibitor and 10 M p38 inhibitor had no effect on, BPC-157-induced proliferation, migration, and tube formation
However, the scale and consistency of patient-reported experiences have suggested that these signals merit further investigation
6 The signal was small overall but more visible in women (1% vs 0.2%) and in adults aged 75 and over (2.4% vs 0.6%)
What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology
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