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No single or dual-agonist compound can replicate the combined effects on appetite regulation, insulin secretion, lipolysis, and thermogenesis that retatrutide produces in research settings

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Of course, you can also consider using a non-hormonal option, like the copper IUD or condoms, if you dont want to worry about drug interactions (condoms are also the only method that protects against STIs)

Sources & references 1Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist - PMC , GLP-1 GIP , 2FDA Approves Monthly KwikPen Option for Tirzepatide - AJMC FDA ( 2022 Mounjaro, 2023 Zepbound), SURMOUNT-1 SURMOUNT-5, 3Tirzepatide: A novel, first-in-class, dual GIP/GLP-1 receptor agonist - ScienceDirect , C20 , 4Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism - DMJ GIP , , 5Tirzepatide - StatPearls - NCBI Bookshelf , , FAQ Tirzepatide is the active ingredient in Mounjaro