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European Teratology Information Services Study (BMJ 2024) Design: Prospective observational cohort Sample: 168 GLP-1 RA-exposed pregnancies, compared with diabetic and obese reference groups Findings: Major birth defect rates: 2.6% (GLP-1 RA) vs

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Whilst the US Food and Drug Administration (FDA) has approved five drug therapies to treat obesity (orlistat, phentermine/topiramate, lorcaserin, naltrexone/bupropion, liraglutide), the European Medicines Agency (EMA) has approved only three drug therapies (orlistat, bupropion/naltrexone and liraglutide) [8] at the time of writing

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Using PSM on age at index, BMI, metformin and statin exposure, BRCA mutation status, hormonal contraceptive use, parity, breastfeeding history, and smoking status, they identified 2 balanced cohorts: 74,354 GLP-1 RAexposed women and 74,355 controls (total n = 148,709)