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19 Given the possibility that existing GLP-1 drugs are insufficient for treating Alzheimers and Parkinsons disease, some researchers are studying new versions of GLP-1s designed to solve that exact problem
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Orforglipron's signaling profile has been characterized in the peer-reviewed publication in Science Translational Medicine in 2024, which reported that orforglipron demonstrates a Gs-biased signaling profile with relatively reduced beta-arrestin recruitment compared to peptide agonists
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