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Eating protein and vegetables before carbohydrates at each meal, choosing complex carbohydrates over refined ones and spacing meals to avoid prolonged fasting followed by large carb loads all help manage the insulin response

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[42] reported that insulin resistance induced by 5 days of HCHF feeding (as assessed by HOMA-IR) also increased the expression of various macrophage markers (for example cluster of differentiation CD68, CD14 and CD11c) in skeletal muscle and reduced the markers of insulin signalling (solute carrier family transporter SLC2A and glycogen synthase-1)

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Together, these results showed that GLP-1R may play an essential role in ER stress-induced inflammatory pathways