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Interaction uncertainty Separate safety data does not tell us how two investigational compounds behave together
: 10 30 .
Moreover, ATZ markedly elevated malondialdehyde levels, suppressed the activities of endogenous antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase), and downregulated the transcription of key steroidogenic genes ( HSD3B , StAR and CYP11A1 )
This association remained robust after adjusting for confounding factors and was consistent across different analytical models
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