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Also, the oxygen cost of myocardial work of isolated old rat hearts pretreated with GSH was significantly decreased (Table 3) which means more effective oxygen utilization by myocardium and usage of oxygen for ATP production, not for ROS

These include but are likely not limited to chronic hyperglycemia, hypertension, dyslipidemia, obesity, insulin resistance, sodium retention, neurohormonal activation and low-grade inflammation, all related to the metabolic syndrome [9, 10]

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