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(PubMed) Bone RC, Balk RA, Cerra FB, et al

Key factors include: Repetitive jumping or running on hard surfaces Sudden increase in training intensity, frequency, or duration Poor training technique, inadequate warm-up, or muscle imbalances Tight or inflexible quadriceps and hamstrings Weakness in glute or core muscles Inadequate footwear or improper support during exercise Previous knee injury, chronic illness, or underlying structural issues Athletes in jumping or sprinting sports, as well as those returning from a period of inactivity too quickly, are especially at risk

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HGH also carries a substantially higher cost, typically ranging from $1,000 to $3,000 per month