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GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas
IGF-I production by adult rat hepatocytes is stimulated by transforming growth factor-a and transforming growth factor-b1
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Konopleva M, Hayes K, Pierce S, Zhao L, Andreeff M , Glasman E, Freireich E, Estey E
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