In a randomized control trial, valproate alone was found to show poorer outcomes for infants than valproate plus levetiracetam in terms of reduction of seizures, freedom from seizures, daily living ability, quality of life, and cognitive abilities
Preclinical Research Summary Rodent studies have evaluated ipamorelin in experimental systems modeling glucocorticoid-associated alterations in bone, muscle, and nitrogen metabolism (osteoblastic activity markers, bone formation indices, nitrogen-balance-related measurements)
increase of RNA synthesis
JAMA 282(18): 173744
Patients should also have a clear plan for what happens if the medication is stopped, changed, unavailable, not tolerated, or no longer needed