Polymorphisms in GSTT1, GSTM1, NAT2, and CYP3A4 affect glutathione synthesis capacity and drug-metabolizing enzyme activity
Some signs that you should extend your current dose period before escalating include diarrhea that occurs more than 3 times daily, diarrhea that has not improved after 3 weeks at the current dose, significant dehydration symptoms (dark urine, dizziness, dry mouth), or diarrhea that is interfering with daily activities or work
While much research focuses on bariatric surgery patients, the mechanisms of B12 deficiency during rapid weight loss overlap significantly with GLP-1 therapy
It has many other health benefits, making it an important supplement for overall well-being
Since it's a substance your body naturally produces, it's generally very well-tolerated