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A 2016 review by Sikiric and colleagues in Current Neuropharmacology framed BPC-157's effects within a brain-gut axis model, while a 2024 review by Sikiric and colleagues in Pharmaceuticals (Basel) examined the peptide's relationships with multiple neurotransmitter systems

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Because human data remain limited, the safest approach is to avoid self-directed dose changes and use BPC-157 only under medical supervision

Injections are designed to be simple and performed at home

In January 2024, the FDA proposed a rule that would prevent BPC-157 from being used in compounding, classifying it alongside other peptides that lack adequate safety and efficacy data for compounded use 3