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Refrigeration before opening is generally not required but is not harmful if done properly

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Wegovys clinical studies overview lists, among its trials, one 68-week, randomized, double-blind, placebo withdrawal trial. Zepbound describes its Study 4 as an 88-week randomized withdrawal trial in which all patients received open-label ZEPBOUND during a 36-week lead-in period, followed by randomization to either continue ZEPBOUND or switch to placebo for 52 weeks. These are the FDA-reviewed accounts of what happens to people who come off, printed in the label, available to any prescriber

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