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[49] demonstrated that a daily dosage of 2.5 mg lentinan was safe and significantly alleviated the circulating B-cells in elderly subjects for six weeks
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Oestrogen dependence may be due to the upregulation of the 17-hydroxysteroid dehydrogenase-1 and aromatase genes, whereas progesterone resistance may result from the failure of progesterone receptor activation and transcription of progesterone target genes [99]
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