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The most significant concern involves insulin and glucose regulation
B12 deficiency can also lead to the destruction of immature red blood cells in the bone marrow, which can cause jaundice (yellowing of the skin and whites of the eyes)
"The Risk of Thrombocytopenia During Valproic Acid Therapy: A Critical Summary of Available Clinical Data"
Its value comes not from the intact molecule, but from the peptides released during digestion
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