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Moiz A, Filion KB, Toutounchi H, et al

The result is a stable, soluble, long-acting amylin receptor agonist suitable for chronic research protocols properties that native amylin and earlier analogues could not provide

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Phosphatidylinositol-dependent kinase-1 (PDK1) and mammalian target of rapamycin complex 2 (mTORC2) then work in concert to phosphorylate AKTs Thr308 and Ser473 sites, which activates the protein (Hers et al., 2011