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By mimicking the effects of GLP-1, a hormone that regulates appetite and blood sugar, semaglutide helps reduce hunger and support long-term weight management

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These symptoms are a leading cause of treatment discontinuation and are likely related to the delayed gastric emptying induced by GLP-1 RAs 43,44

Conversely, SGLT2 inhibitors are not associated with increased HR despite natriuresis/osmotic diuresis and reduced blood pressure and plasma volume, suggestive of reduced SNS activity 6 , 81

Foundayos inclusion highlights CVS willingness to cover emerging once-daily oral obesity therapy, potentially expanding uptake among injection-averse patients and broadening the treatable commercial population