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Acute or tissue-restricted APJ activation may be appropriate for cardiometabolic indications, whereas chronic systemic exposure may be unsuitable without biased or targeted agonists

These may be influenced by numerous factors including placebo effects, concurrent lifestyle changes, and selection bias

That matters just as much as the trial averages, because for most people, the best medication is not just the one with the highest theoretical ceiling

But compounded semaglutide isn't 'unapproved medication.' It's the same active compound prepared legally under federal compounding regulations when drug shortages exist, which has been continuously documented for semaglutide since March 2023