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Significant differences between treatments were assessed using one-way analysis of variance (ANOVA) followed by Duncans multiple range test

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The intracellular ERO1 in a PDI- independent manner influences Ca 2+ store content and Ca 2+ mobilization by altering the Cys49-Cys56 disulfide bond in stromal interaction molecule 1 (STIM1) and the Cys875-Cys887 disulfide bond in SERCA2, resulting in platelet activation and aggregation (Figure 4B) ( 50 = 7.9 M) results in reduced infarct volume and improved neurological outcomes in ischemic stroke models, indicating that targeting ERO1 may offer potential benefits in stroke treatment

The concentration of l-cysteine was determined by the colorimetric method described by Gaitonde [39] using the reaction with ninhydrin

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