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It antagonizes haloperidol-induced behavioural supersensitivity to amphetamine which, results in dopaminergic neurotoxicity and nigrostriatum damage due to increased lipid peroxidation

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Reported Sex-Based Variability in the Literature Where sex-based data does appear, researchers generally attribute observed variability to differences in baseline endogenous IGF-1 and growth hormone signaling between male and female physiology, rather than to any fundamental difference in how IGF-1 LR3 binds or activates the IGF-1 receptor