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Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance

Alternatives include Wegovy pills , a tablet version containing the same active ingredient, and Mounjaro injections, which target two appetite-related hormones instead of one

Enrolled patients had a baseline or recent liver biopsy showing clinically significant MASLD (metabolic dysfunction-associated steatotic liver disease), defined as MASH with fibrosis stage 2 or 3 and a non-alcoholic fatty liver disease (NAFLD) Activity Score (NAS) 4 with a score of 1 or more in steatosis, lobular inflammation, and hepatocyte ballooning

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5a and Supplementary Fig