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SIRT1 also provides feedback regulation along the ROSmitochondrial damageautophagic dysfunction axis, 102,177,178 reducing oxidative accumulation and repairing mitochondrial metabolic alterations, interrupting the oxidative stressinflammationenergy collapse cycle in MASLD

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Both require baseline hormone assessment and provider oversight before initiation

Exenatide, metformin, or both for prediabetes in PCOS: a randomized, open-label, parallel-group controlled study

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