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For example, lysosome-activatable prodrugs may be more suitable in this context, or LYTAC-mediated degradation can be combined with endosomal escape strategies to enable complementary rather than counterproductive effects
Because these agents inhibit transmission in both sympathetic and parasympathetic ganglia, physiological effects reflect blockade of the predominant resting autonomic tone, including tachycardia (cardiac) and marked orthostatic hypotension (vascular) (middle panel)
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Thats why the amount you drink and how quickly you drink it affect how strongly alcohol impacts you
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