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Chronic high-dose pyridoxine can cause sensory neuropathymanifesting as numbness, tingling, or gait instabilityemphasizing the need for appropriate dosing and periodic reassessment
References StatPearls (NCBI Bookshelf) Farzam K, Patel P
Clinically, this manifests as peripheral neuropathy, characterized by numbness, painful tingling, burning sensations in the extremities, and eventual loss of motor function
Vitamin B12 injections are an effective way to treat a deficiency, but they're not for everyone
More serious reactions are less common but still possible
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