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While cysteine itself has neurotoxic effects mediated by free radical generation, increasing extracellular glutamate and triggering overactivation of N-methyl-D-aspartate (NMDA) receptors [45], GSH is a non-toxic cysteine storage form with 10100 times higher concentrations in mammalian tissues than cysteine [46]

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While GHSR is primarily active in the brain, it is also found in other tissues such as the gastrointestinal tract, heart, lungs, liver, kidneys, pancreas, fat tissue, and immune cells

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