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Swase et al., 2025)
The MCCC1 gene is located on chromosome 3q27.1 and is composed of 23 exons that generate three alternatively spliced mRNAs, two of which are known to encode functional protein
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For example, engineered Escherichia coli Nissle 1917 (EcN) co-expressing anti-PD-L1 and anti-CD9 nanobodies (EcN-Nb) and modified with ICG-loaded zinc-based MOFs to generate EcN-Nb-ZIF-8CHO-ICG (ENZC), can specifically release nanobodies in response to NIR radiation thereby targeting tumor-derived exosomes (TDEs) to alleviate immunosuppression, such as reshaping TAMs to the M1 state and activating more effective and cytotoxic T lymphocytes, ultimately inhibiting tumor proliferation and metastasis (229)
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