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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially developed for the treatment of type 2 diabetes and obesity, may modulate pathways associated with the hallmarks of aging

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2.1.2 Pericyte apoptosis Pericyte apoptosis is universally recognized as the earliest functionally significant and morphologically identifiable lesion in diabetic retinopathy, occurring months to years before microaneurysms become visible clinically

In lab studies, it's shockingly potent at boosting collagen, even at concentrations a billion times smaller than most drugs

It does mean that summer skin may already be working harder, especially in people with vitiligo or a known tendency toward pigment instability