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doi:10.1007/s00210-016-1247-1

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Succinic semialdehyde (4-oxobutanoate) acts as a suitable substrate analog` as this molecule only lacks the 3-hydroxy group of MSA (3-hydroxy-4-oxobutanoate) which could be added in silico

For example, a notable trial involving young men with ASD revealed a 34% improvement in behavior assessed by the Aberrant Behavior Checklist (ABC) and a 17% improvement in social responsiveness measured by the Social Responsiveness Scale (SRS) after 18 weeks of daily oral supplementation

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