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These picomolar levels of 15-HpETE-PE alone (Supplemental Figure 4A, generated under IL-13 plus arachidonic acid conditions) would be insufficient to directly oxidize the nanomolar changes caused by oxidation of GSH to GSSG observed in response to IL-13 (or the change with inhibition of 15LO1 or KD of ALOX15 /15LO1)

TABLE 3 Statistical summary of the effects of the semaglutide and high fat diet combination on alcohol intake in male and female rats

We conducted the literature search on PubMed and Embase (Ovid) in December 2023 and updated it in June 2024