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Kauvar says, but adds that there is no evidence to date of any toxicity at the concentrations currently used

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On the contrary, some HSV-1-induced H2AX foci were still detected in neurons infected in the presence of PAA (Figures 2B,d,h) that blocks viral DNA synthesis, but not transcription of early genes, suggesting that viral DNA replication is not essential but may partly contribute to the accumulation of H2AX