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Transient activation of AMPK can inhibit protein synthesis through phosphorylation of elongation factor-2 kinase 37 and suppression of the mTOR pathway 38 , thus enhancing the restoration of cellular energy homeostasis and alleviating the burden of the unfolded nascent polypeptides 31

Healing was evaluated by macroscopic appearance, microscopic histology, and biomechanical testing across the 90-day timeline

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