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Serious Indicators of Vitamin B-12 Deficiency Severe vitamin B12 deficiency can cause signs and symptoms such as Yellow skin Weak muscles Numb or tingly hands or feet Trouble walking Severe joint pain Increasing shortness of breath Weight loss Irritability Lack of smell and taste sensations Memory loss Paranoia Delusions Deep depression What Does B12 Fatigue Feel Like

A clinician should decide whether treatment can be reduced, changed or stopped

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Standard subcutaneous injection sites include the abdominal area (at least 2 inches from navel), thighs, and upper arms

Those taking proton pump inhibitors might also have trouble absorbing it