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Extra caution is important with: Frequent vomiting or suspected cannabinoid hyperemesis Symptoms of gastroparesis, including early fullness, nausea, vomiting, bloating, and upper abdominal pain Diabetes medications that can cause low blood sugar, including insulin or sulfonylureas Heavy cannabis use, high THC products, or unpredictable edibles dosing Prior dehydration, severe constipation, pancreatitis, or unexplained severe abdominal pain Very low appetite, unintended weight loss, or eating disorder history Multiple sedating substances Upcoming surgery, anesthesia, endoscopy, colonoscopy, or gastric emptying testing GLP-1 medications can delay gastric emptying, which also matters for procedures and anesthesia planning

Karelis AD, Messier V, Suppere C, Briand P, Rabasa-Lhoret R

Discussion Aside from the top 10% of responders in our real-world study, we found that GLP-1s resulted in smaller reductions in both weight loss and HbA1c, respectively

Children with PWS may also be at risk for central adrenal insufficiency, a potentially life-threatening condition marked by low levels of the cortisol hormone due to problems in certain brain regions

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