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18.2% average weight loss at week 68 was observed in patients in the STEP 4 trial, along with reduced blood glucose levels, improved lipid profile and significant improvements in overall quality of life and health status scores
Change history 17 June 2026 In the version of this article initially published online, there were duplication errors in the Extended Data Fig
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Availability of multi-omic data (DNA, RNA, protein, PTM, metabolite) types per patient
There are several reasons people might want to switch: Weight loss plateaus after a few months on semaglutide Gastrointestinal side effects like nausea or constipation that are not manageable Desire for better glucose control Personal goals (e.g., prefer faster weight loss progress ) In my practice, the most common reasons I recommend patients to switch medication is 1) they are having uncomfortable or unmanageable side effects from semaglutide including heart burn, nausea, constipation or 2) their weight loss starts to plateau before they reach their weight loss goals
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