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The success of this approach depends on the precise engineering of receptor selectivity, potency ratios, and pharmacokinetics to maximize efficacy while minimizing adverse events

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It reversed glucose dysregulation without detrimental effects on metabolically healthy animals and reduced body weight, lowered fasting blood glucose, decreased glycosylated hemoglobin (HbA1C), improved glucose tolerance, and protected pancreatic islet architecture in diabetic fatty Zucker rats 22,23,24

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