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16, 77, 78 We found several signaling cascades are activated by liraglutide in PSCs including ERK, JNK, p38, Akt and I B

Briefly, enzyme activity was determined at 37C in reaction mixtures of 1.0 ml containing 100 mm Tris-HCl buffer (pH 8.2), 150 mm KCl, 5 mm ATP, 2 mm phosphoenolpyruvate, 10 mm glutamate, 10 mm -aminobutyrate, 20 mm MgCl 2 , 2 mm EDTA, 0.2 mm NADH, 17 g pyruvate kinase, and 17 mg lactate dehydrogenase

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Cardiovascular safety trial demonstrating that the DPP-4 inhibitor alogliptin does not increase MACE in patients with T2DM who had a recent acute coronary event

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