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Avoid dosing late in the day if you're sensitive to energy fluctuations, as some users report difficulty sleeping when taking it in the afternoon or evening

Rodriguez P et al

For instance, it appears that, at the onset of cell proliferation in the early G1 phase, an increase of ROS in the cytoplasm is necessary for the initiation of the phosphorylation cascade mediated by epidermal growth factor (EGF) that, subsequently, activates DNA replication and the cell division ([55])

Curtis BR, McFarland JG, Wu GG, Visentin GP, Aster RH

This careful escalation exists because gastrointestinal side effects can be significant