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We confirmed this effect using an orthogonal viral strategy: Cre-dependent expression of the danuglipron-sensitive mouse Glp1r S33W variant in CeA neurons reproduced HFD suppression, whereas expression of the WT mouse Glp1r served as an unresponsive control (Extended Data Fig
Furthermore, the overall diversity and composition of the gut microbiome may indirectly influence GLP-1 production and signaling in the gut, thereby impacting various metabolic processes relevant to weight management
Postgraduate Medical Journal , 100 (1179), 35-42
primer for the pathway-level background
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