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& Chang, C

A placebo-controlled trial shows that 6mg of supplemental melatonin decreases inflammatory markers (TNF-alpha, IL-6, and CRP) in obese women.[ref] A meta-analysis of a bunch of studies found that melatonin consistently reduces CRP and IL-6 in people with metabolic syndrome.[ref] Several studies have shown that supplemental melatonin (along with diet) increases weight loss.[ref][ref] Diabetes: Adding melatonin with exercise cures insulin resistance, hypertension, and fatigue in an animal model of diabetes.[ref] But what about humans

PMID 23631642

Daily application produces optimal results

In brainstem/pons, the meta-analysis did find functional connectivity but failed to find consistent activation across studies in the area of nucleus of the solitary tract (NTS) and area postrema